Target Cursor Location
/cast [@cursor] ABILITYNAME

Target Player Location
/cast [@player] ABILITYNAME

Player & Cursor Modifier
#showtooltip Sigil of Flame
/cast [mod:alt, @player][@cursor][] ABILITYNAME

Help/Harm Mouseover Macro
/cast [@mouseover,nodead,exists,harm][nodead,harm] HARM_ABILITY_NAME; [@mouseover,nodead,exists][help][]HELP_ABILITY_NAME

Mouseover Macro
/cast [@mouseover] ABILITYNAME

Enhanced Autorun
/run if not MovePadFrame then UIParentLoadAddOn"Blizzard_MovePad"MovePadFrame:Hide()end
/click MovePadForward
/run if IsMouselooking() then MouselookStop() else MouselookStart() end

ADDONS
Video 1: https://www.youtube.com/watch?v=GLz4YV4Z6Mc
Video 2: https://www.youtube.com/watch?v=vht88eQtrt8
Dialogue Keys: https://mods.curse.com/addons/wow/dialogkey
OPie: https://mods.curse.com/addons/wow/opie
Immersion: https://mods.curse.com/addons/wow/257550-immersion
Weakauras: https://mods.curse.com/addons/wow/weakauras-2
DynamicCam: https://mods.curse.com/addons/wow/dynamiccam